Dear Colleagues

Genomic instability is a characteristic of practically all human cancers. This often involves gross chromosomal abnormalities such as deletion and duplication of chromosomes or chromosome parts, chromosomal rearrangements and mitotic recombinations, generally termed as “chromosomal instability''. Other types of genomic instability are characterized by an increased rate of small-scale genetic changes (such as microsatellite instability). The role of genomic instability (GI) for cancer progression is a very important, yet unresolved question.
The goal of the advanced course is to bring together people who study the phenomenon of GI and the pathways of response from different prospective, for extended discussions and learning. In particular we hope to start a dialog between internationally accepted outstanding scientists and young researchers. It will provide participants a clear overview of the challenges and opportunities that exist in this new and exciting field, as well as concise and practical support of commonly used approaches.

Organizing Committee




IMPORTANT DATES
Application submission Deadline: 10 OCTOBER 2010 
FEBS Youth Travel Grants Application Deadline: 10 OCTOBER 2010 

SPECIAL LECTURER

 

Dr. Tim Hunt

Nobel Prize Laureate in Physiology or Medicine
Laboratory of Cell Cycle Control
London Research Institute, UK

Prof. Hunt was born on 19 February, 1943 in Neston (UK). In 1961 he was accepted into Clare College, Cambridge to study Natural Sciences, graduating in 1964 and immediately beginning work in the university Department of Biochemistry under Asher Korner, working with scientists such as Louis Reichardt and Tony Hunter. While doing summer work in 1982 at the Marine Biological Laboratory at Woods Hole, Massachusetts, using the sea urchin (Arbacia punctulata) egg as his model organism, he discovered the cyclin molecule. Hunt found that cyclins begin to be synthesised after the eggs are fertilized and increase in levels during interphase, until they drop very quickly in the middle of mitosis in each cell division. He also found that cyclins are present in vertebrate cells where they also regulate the cell cycle. He and others subsequently showed that the cyclins bind and activate a family of protein kinases, now called the cyclin-dependent kinases, one of which had been identified as a crucial cell cycle regulator by Paul Nurse. He became a fellow of the Royal Society in 1991 and a foreign associate of the U.S. National Academy of Sciences in 1999. In 2001 he was awarded the Nobel Prize in Physiology or Medicine with Leland Hartwell and Sir Paul Nurse for their discoveries regarding cell cycle regulation by cyclin and cyclin-dependent kinases. In 2006 he was awarded the Royal Medal for 'discovering a key aspect of cell cycle control, the protein cyclin which is a component of cyclin dependent kinases, demonstrating his ability to grasp the significance of the result outside his immediate sphere of interest'. He was knighted by the Queen in the same year. 

 

KEYNOTE LECTURERS INCLUDE 

Dr. Rouben Aroutiounian
Department of Genetics and Cytology
Yerevan State University, ARM 

Dr. Anna Boyajyan
Laboratory of Macromolecular Complexes
Institute of Molecular Biology of NAS, ARM

Dr.Walter Doerfler - EMBO Plenary Lecture
Institute for Clinical and Molecular Virology
Erlangen University Medical School, Germany 

Dr. Genady Gasparyan
Department of Genetics and Cytology
Yerevan State University, ARM

Dr. Nora Goosen
Faculty of Science
University of Leiden, NDL

Dr. Eric Greene
Department of Biochemistry and Molecular Biophysics
Columbia University, USA 

Dr. Greg Hampikian
Department of Biology
Boise State University, USA

Dr. Zaven Karalyan
Laboratory of Cell Biology
Insitute of Molecular Biology of NAS, ARM

Dr. Haig Kazazian
Department of Genetics
University of Pennsylvania, USA

Dr. Peter J. McHugh
The Weatherall Institute of Molecular Medicine
University of Oxford, UK

Dr. Michael Neuberger
PNAC Division
University of Cambridge, UK

Dr. Pier Lorenzo Puri
Laboratory of Gene Expression
Dulbecco Telethon Institute, ITA

Dr. Janos Szabad
Faculty of Medicine,
University of Szeged, HUN

Dr. Yuri Tadevosyan
Laboratory of Cell activity regulation
Institute of molecular Biology of NAS, ARM

Dr. Susan S. Wallace - IUBMB Speaker
Department of Cell and Molecular Biology
The University of Vermont, USA

Dr. Mitsuhiro Yanagida
Graduate School of Biostudies,
Kyoto University, JPN

Dr. Virginia Zakian
Department of Molecular Biology
Princeton University, USA

 


                  

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